Guardiola said his side must not only beat Liverpool to win the title, but the favouritism towards them around the world after City moved three points clear at the top.
And the City boss could not resist a dig at Liverpool’s record of winning a solitary league title in the last three decades.
“Everyone in this country supports Liverpool, the media and everyone, of course, because Liverpool has an incredible history behind in European competition,” said Guardiola.
“Not in the Premier League, because they’ve won one in 30 years – but it’s not a problem at all. The situation is what it is.
“Liverpool, alongside Manchester United, are the most famous team, with what they have done in history in terms of titles, legacy, history, drama – for many, many things.
“But we are, for the last 10, 11, 12 years, coming there. I know we’re sometimes uncomfortable, but I don’t care.
“The people want Liverpool to win more than us. It’s not an issue. It’s normal. Maybe they have more supporters all around the world and in England maybe more support Liverpool than us.
“But the question is today. Before the start of the game, the people were cheering and supporting us – they know that even being out of the Champions League, we can rely on those players.
“We need nine points or maybe six right now, it depends what happens in the next two games in terms of goal difference.
“But now, Wednesday at Wolves is the real, real final for us. We’re going to try to win there. Our destiny is in our hands.”
Guardiola also revealed defenders Kyle Walker, Ruben Dias and John Stones are out for the season, meaning he may have to play midfielders Fernandinho and Rodri in defence.
“Ruben, Kyle and John are out for the season,” said Guardiola. “Nathan Ake also has a problem in the ankle.”
Raheem Sterling scored twice, with further goals from Aymeric Laporte, Rodri and Phil Foden giving City a comfortable win, which increased their goal difference to four over Liverpool.
Newcastle boss Eddie Howe said: “City can do that to anybody, they’re that good. We didn’t get the details right today.”